About Gene List

PF3D7_0416700

Genome location: Pf3D7_04_v3:727,456..728,891(-)

Genome classification: Core

Function and Localization

Product Description: CDGSH iron-sulfur domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.05 0.98
Trophozoite no data 0.26 0.83
Schizont no data 0.28 0.81
Gametocyte no data 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0416700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.987 | MFS: 1.286 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0718700)

  • Relative Growth Rate: 0.96 ± 0.10
  • Confidence: 6.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0718700)

Modification: Disrupted | RMgm-2269

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4A8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
B0K020 CDGSH iron-sulfur domain-containing protein 1 OrthoDB, OrthoMCL BLAST RosiglitazonePioglitazoneCHEMBL602048
Q9NZ45 CDGSH iron-sulfur domain-containing protein 1 Homo sapiens OrthoDB, OrthoMCL BLAST US8877795, 12CHEMBL230515CHEMBL3901608CHEBI:3962...
Q8N5K1 CDGSH iron-sulfur domain-containing protein 2 OrthoDB, OrthoMCL BLAST PioglitazoneRosiglitazone

Orthology Information

Ortholog Group (OrthoMCL): OG6_151815

No human ortholog(s)

Protein Information

Protein Length: 89 | Molecular Weight (kDa): 10.238

UniProt ID(s): C0H4A8

PDB ID(s): None

Isoelectric Point: 10.83

Protein Domain Annotations:

Source Family ID Description
InterPro IPR018967 Iron sulphur-containing domain, CDGSH-type
PFam PF09360 Iron sulphur-containing domain, CDGSH-type
Superfamily N/A N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 1 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 2 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 103

Non-coding: 101 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 1

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21