Product Description: small GTP-binding protein sar1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030127 | COPII vesicle coat |
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0070971 | endoplasmic reticulum exit site |
| Component | GO:0020020 | food vacuole |
| Function | GO:0003924 | GTPase activity |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0061024 | membrane organization |
| Process | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum |
| Process | GO:0003400 | regulation of COPII vesicle coating |
| Process | GO:0016050 | vesicle organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.58 | 0.73 |
| Trophozoite | expressed | 1.56 | 0.29 |
| Schizont | expressed | 0.69 | 0.64 |
| Gametocyte | expressed | 0.48 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0416800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.131 | MFS: -2.831 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1S0
"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=0.06) with 2H57 (Global RMSD=2.95)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101164
Most Similar Human Ortholog: D6RD69
TM-align score: 0.92 | RMSD: 1.28
Seq Identity: 0.50 | Length: 163 / 192
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000079332 | secretion associated Ras related GTPase 1A |
| ENSG00000152700 | secretion associated Ras related GTPase 1B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 2 | 5 | 13 |
| disruptive | 1 | 1 | 1 | 8 |
| missense | 1 | 1 | 1 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 20 | 1 | 16 |
| disruptive | 1 | 14 | 15 | 60 |
| missense | 1 | 8 | 13 | 43 |
PlasmoDB Total SNPs: 126
Non-coding: 126 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 192 | Molecular Weight (kDa): 22.02
PDB ID(s): None
Isoelectric Point: 7.24
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR006689 | Small GTPase superfamily, ARF/SAR type |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00025 | Small GTPase superfamily, ARF/SAR type |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10472798 | A homologue of Sar1p localises to a novel trafficking pathway in malaria-infectederythrocytes. | Albano FR, Berman A, ..., Tilley L | 10.1016/S0171-9335(99)80072-7 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17428488 | Re-assessing the locations of components of the classical vesicle-mediatedtrafficking machinery in transfected Plasmodium falciparum. | Adisa A, Frankland S, ..., Tilley L | 10.1016/j.ijpara.2007.02.009 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 22982544 | Structural characterization and inhibition of the Plasmodium Atg8-Atg3interaction. | Hain AU, Weltzer RR, ..., Bosch J | 10.1016/j.jsb.2012.09.001 |