PF3D7_0417000

Genome location: Pf3D7_04_v3:741,816..743,452(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.50	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0417000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.262 | MFS: -2.667 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1R8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533404

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	2	1	6
disruptive	3	4	7	13
missense	3	4	6	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	5	8	10
disruptive	8	14	12	53
missense	3	11	11	35

PlasmoDB Total SNPs: 78

Non-coding: 65 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 275 | Molecular Weight (kDa): 32.865

UniProt ID(s): Q8I1R8

PDB ID(s): None

Isoelectric Point: 9.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A