Product Description: LETM1-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0006875 | cellular metal ion homeostasis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.82 |
| Trophozoite | expressed | 0.79 | 0.58 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | expressed | 0.63 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0417300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.291 | MFS: -3.298 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1R5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101861
Most Similar Human Ortholog: O95202
TM-align score: 0.39 | RMSD: 4.48
Seq Identity: 0.23 | Length: 331 / 802
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000168924 | leucine zipper and EF-hand containing transmembrane protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 7 | 12 | 16 |
| disruptive | 6 | 12 | 14 | 52 |
| missense | 4 | 6 | 10 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 31 | 20 | 37 |
| disruptive | 18 | 82 | 63 | 132 |
| missense | 5 | 42 | 42 | 89 |
PlasmoDB Total SNPs: 176
Non-coding: 102 | Synonymous: 65 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 802 | Molecular Weight (kDa): 95.487
UniProt ID(s): Q8I1R5
PDB ID(s): None
Isoelectric Point: 9.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011685 | LETM1-like |
| PFam | PF07766 | LETM1-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |