PF3D7_0417400

Genome location: Pf3D7_04_v3:755,176..777,060(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.93	0.31
Trophozoite	expressed	2.53	0.11
Schizont	expressed	2.08	0.27
Gametocyte	expressed	2.17	0.16

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0417400

Resistome Missense Mutations: I3027K, D5375N

Resistome Compounds with Missense Mutations: AN13762, Suloctidil

Resistome # Samples with Disruptive Mutations: 3 (2 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.17 | MFS: -2.817 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533162

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	63	213	122	278
disruptive	460	801	348	972
missense	255	525	274	711

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	100	415	199	360
disruptive	818	1530	691	1511
missense	400	993	508	987

PlasmoDB Total SNPs: 1057

Non-coding: 87 | Synonymous: 522 | Nonsynonymous: 446 | Stop Codon: 2

Protein Information

Protein Length: 6769 | Molecular Weight (kDa): 822.389

UniProt ID(s): C0H4B0

PDB ID(s): None

Isoelectric Point: 9.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A