PF3D7_0417500

Genome location: Pf3D7_04_v3:776,801..779,987(-)

Genome classification: Core

Function and Localization

Product Description: memo-like protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0417500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.353 | MFS: -2.456 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0719600)

Relative Growth Rate: 1.00 ± 0.11
Confidence: 5.72

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0719600)

Modification: Disrupted | RMgm-2271

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4B1

"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=0.37) with 7KQ8 (Global RMSD=2.09)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101032

Most Similar Human Ortholog: Q9Y316

TM-align score: 0.94 | RMSD: 1.38

Seq Identity: 0.36 | Length: 289 / 296

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000162959	mediator of cell motility 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	11	24
disruptive	1	15	7	28
missense	1	15	7	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	37	12	15
disruptive	3	41	17	40
missense	3	36	16	29

PlasmoDB Total SNPs: 203

Non-coding: 191 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 296 | Molecular Weight (kDa): 34.295

UniProt ID(s): C0H4B1

PDB ID(s): None

Isoelectric Point: 7.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002737	MEMO1 family
PFam	PF01875	MEMO1 family
Superfamily	N/A	N/A