PF3D7_0417600

Genome location: Pf3D7_04_v3:780,243..783,375(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.07	0.96
Schizont	expressed	0.13	0.92
Gametocyte	expressed	0.64	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0417600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.07 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1R1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532374

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	21	16	43
disruptive	34	66	35	86
missense	30	50	31	71

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	42	27	47
disruptive	52	140	59	155
missense	37	104	47	109

PlasmoDB Total SNPs: 197

Non-coding: 65 | Synonymous: 79 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 807 | Molecular Weight (kDa): 96.264

UniProt ID(s): Q8I1R1

PDB ID(s): None

Isoelectric Point: 4.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A