PF3D7_0417900

Genome location: Pf3D7_04_v3:790,709..793,086(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.11	0.94
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.65	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0417900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.805 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Q8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532511

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	26	15	29
disruptive	59	63	45	155
missense	30	53	30	133

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	49	31	42
disruptive	79	200	98	210
missense	41	141	73	148

PlasmoDB Total SNPs: 159

Non-coding: 34 | Synonymous: 61 | Nonsynonymous: 63 | Stop Codon: 1

Protein Information

Protein Length: 753 | Molecular Weight (kDa): 91.153

UniProt ID(s): Q8I1Q8

PDB ID(s): None

Isoelectric Point: 8.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A