PF3D7_0418000

Genome location: Pf3D7_04_v3:793,749..810,923(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005789	endoplasmic reticulum membrane
Component	GO:0005634	nucleus
Function	GO:0003700	DNA-binding transcription factor activity
Function	GO:0043565	sequence-specific DNA binding
Process	GO:0045893	positive regulation of transcription, DNA-templated
Process	GO:0016540	protein autoprocessing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.11	0.95
Trophozoite	no data	0.34	0.83
Schizont	no data	0.79	0.62
Gametocyte	no data	1.89	0.27

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0418000

Resistome Missense Mutations: K3634R

Resistome Compounds with Missense Mutations: AN10248

Resistome # Samples with Disruptive Mutations: 3 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.427 | #Insertions: 14

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533164

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	51	202	113	276
disruptive	212	622	363	837
missense	138	495	306	679

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	83	405	182	305
disruptive	402	1369	660	1227
missense	235	1030	545	850

PlasmoDB Total SNPs: 825

Non-coding: 324 | Synonymous: 283 | Nonsynonymous: 218 | Stop Codon: 0

Protein Information

Protein Length: 4891 | Molecular Weight (kDa): 583.95

UniProt ID(s): C0H4B3

PDB ID(s): None

Isoelectric Point: 8.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A