About Gene List

PF3D7_0418100 (SOC1)

Genome location: Pf3D7_04_v3:810,171..815,760(-)

Genome classification: Core

Function and Localization

Product Description: protein SOC1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Function GO:0019888 protein phosphatase regulator activity
Process GO:0043666 regulation of phosphoprotein phosphatase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.61 0.71
Trophozoite expressed 0.37 0.79
Schizont expressed 0.15 0.91
Gametocyte expressed 0.55 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0418100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.23 | MFS: -2.648 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0720200)

  • Relative Growth Rate: 0.83 ± 0.12
  • Confidence: 5.55

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0720200)

Modification: Tagged | RMgm-4152

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Q6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100938

Most Similar Human Ortholog: K7EM28

TM-align score: 0.88 | RMSD: 2.26

Seq Identity: 0.24 | Length: 156 / 1215

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000100239 protein phosphatase 6 regulatory subunit 2
ENSG00000105063 protein phosphatase 6 regulatory subunit 1
ENSG00000110075 protein phosphatase 6 regulatory subunit 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 65 35 70
disruptive 80 189 80 181
missense 48 114 59 128

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 127 44 79
disruptive 157 348 150 371
missense 83 231 109 198

PlasmoDB Total SNPs: 367

Non-coding: 164 | Synonymous: 117 | Nonsynonymous: 86 | Stop Codon: 0

Protein Information

Protein Length: 1215 | Molecular Weight (kDa): 144.834

UniProt ID(s): Q8I1Q6

PDB ID(s): None

Isoelectric Point: 4.65

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007587 SIT4 phosphatase-associated protein family
PFam PF04499 SIT4 phosphatase-associated protein family
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28481199 Multiple short windows of calcium-dependent protein kinase 4 activity coordinatedistinct cell cycle events during Plasmodium gametogenesis Fang H, Klages N, ..., Brochet M 10.7554/eLife.26524