Product Description: eukaryotic translation initiation factor 3 subunit M, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0002183 | cytoplasmic translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.44 | 0.79 |
| Trophozoite | expressed | 0.43 | 0.74 |
| Schizont | expressed | 0.10 | 0.93 |
| Gametocyte | expressed | 0.21 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0418200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.135 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1Q5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103094
Most Similar Human Ortholog: H0YCQ8
TM-align score: 0.82 | RMSD: 2.25
Seq Identity: 0.19 | Length: 208 / 429
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000149100 | eukaryotic translation initiation factor 3 subunit M |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 21 | 13 | 19 |
| disruptive | 2 | 7 | 5 | 34 |
| missense | 2 | 7 | 5 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 50 | 16 | 30 |
| disruptive | 3 | 43 | 32 | 114 |
| missense | 3 | 32 | 26 | 55 |
PlasmoDB Total SNPs: 181
Non-coding: 170 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 429 | Molecular Weight (kDa): 51.03
UniProt ID(s): Q8I1Q5
PDB ID(s): None
Isoelectric Point: 7.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000717 | Proteasome component (PCI) domain |
| InterPro | IPR027528 | Eukaryotic translation initiation factor 3 subunit M |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| PFam | PF01399 | Proteasome component (PCI) domain |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |