PF3D7_0418400

Genome location: Pf3D7_04_v3:829,728..830,676(+)

Genome classification: Core

Function and Localization

Product Description: LSM domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.13	0.92
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0418400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.289 | MFS: -0.873 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Q3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533625

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	5	3	5
disruptive	2	6	8	11
missense	2	4	8	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	9	10	6
disruptive	4	21	11	22
missense	3	17	8	16

PlasmoDB Total SNPs: 57

Non-coding: 47 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 109 | Molecular Weight (kDa): 12.805

UniProt ID(s): Q8I1Q3

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010920	LSM domain superfamily
PFam	N/A	N/A
Superfamily	SSF50182	LSM domain superfamily