Product Description: trafficking protein particle complex subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030008 | TRAPP complex |
| Component | GO:0033106 | cis-Golgi network membrane |
| Component | GO:0005829 | cytosol |
| Function | GO:0003723 | RNA binding |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.21 | 0.86 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | expressed | 0.11 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0418500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.04 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0720600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0720600)
Modification: Disrupted | RMgm-2275
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1Q2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102403
Most Similar Human Ortholog: O43617
TM-align score: 0.91 | RMSD: 1.32
Seq Identity: 0.52 | Length: 171 / 187
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000054116 | trafficking protein particle complex 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 7 | 3 |
| disruptive | 3 | 6 | 1 | 17 |
| missense | 3 | 6 | 1 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 5 | 13 |
| disruptive | 4 | 23 | 14 | 31 |
| missense | 3 | 18 | 12 | 20 |
PlasmoDB Total SNPs: 159
Non-coding: 152 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 187 | Molecular Weight (kDa): 21.316
UniProt ID(s): Q8I1Q2
PDB ID(s): None
Isoelectric Point: 4.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007194 | Transport protein particle (TRAPP) component |
| InterPro | IPR016721 | Bet3 family |
| InterPro | IPR024096 | NO signalling/Golgi transport ligand-binding domain superfamily |
| PFam | PF04051 | Transport protein particle (TRAPP) component |
| Superfamily | SSF111126 | NO signalling/Golgi transport ligand-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17428488 | Re-assessing the locations of components of the classical vesicle-mediatedtrafficking machinery in transfected Plasmodium falciparum. | Adisa A, Frankland S, ..., Tilley L | 10.1016/j.ijpara.2007.02.009 |
| 24086721 | Comparative genomic analysis of multi-subunit tethering complexes demonstrates anancient pan-eukaryotic complement and sculpting in Apicomplexa. | Klinger CM, Klute MJ, Dacks JB | 10.1371/journal.pone.0076278 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |