About Gene List

PF3D7_0418600

Genome location: Pf3D7_04_v3:833,620..840,678(+)

Genome classification: Core

Function and Localization

Product Description: regulator of chromosome condensation, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.45 0.84
Trophozoite possibly expressed 0.14 0.92
Schizont expressed 1.21 0.62
Gametocyte expressed 0.28 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0418600

Resistome Missense Mutations: V1181E

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 4 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.628 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0720700)

Modification: Disrupted | RMgm-2276

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Q1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533425

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 28 79 52 118
disruptive 130 274 134 326
missense 59 184 95 243

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 45 145 74 131
disruptive 215 468 205 519
missense 98 319 162 350

PlasmoDB Total SNPs: 407

Non-coding: 111 | Synonymous: 165 | Nonsynonymous: 131 | Stop Codon: 0

Protein Information

Protein Length: 2011 | Molecular Weight (kDa): 236.358

UniProt ID(s): Q8I1Q1

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFam PF13540 N/A
Superfamily SSF50985 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
24841368 Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. Butler CL, Lucas O, ..., White M 10.1371/journal.pone.0097625