About Gene List

PF3D7_0418800

Genome location: Pf3D7_04_v3:843,562..845,169(+)

Genome classification: Core

Function and Localization

Product Description: CRONE protein, putative

SignalP Peptide: MNCVFFLCLYIFLGSVVH

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044312 crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.00 1.00
Trophozoite expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte expressed 0.70 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0418800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.341 | MFS: -2.465 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0720900)

  • Relative Growth Rate: 1.06 ± 0.13
  • Confidence: 5.51

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0720900)

Modification: Tagged | RMgm-5353

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4B4

"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=10.74) with 2PMI (Global RMSD=16.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132762

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 11 5 20
disruptive 1 4 6 17
missense 1 4 5 16

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 20 17 23
disruptive 5 14 14 41
missense 1 12 14 29

PlasmoDB Total SNPs: 138

Non-coding: 132 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 261 | Molecular Weight (kDa): 30.215

UniProt ID(s): C0H4B4

PDB ID(s): None

Isoelectric Point: 7.94

Protein Domain Annotations:

Source Family ID Description
InterPro IPR033438 Modulator of levamisole receptor-1
PFam PF17175 Modulator of levamisole receptor-1
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
25418785 Genome-wide RIP-Chip analysis of translational repressor-bound mRNAs in thePlasmodium gametocyte. Guerreiro A, Deligianni E, ..., Mair GR 10.1186/s13059-014-0493-0