PF3D7_0418900

Genome location: Pf3D7_04_v3:846,888..849,541(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.33	0.80
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.88	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0418900

Resistome Missense Mutations: W290L

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.197 | MFS: -2.694 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0721000)

Relative Growth Rate: 1.00 ± 0.13
Confidence: 5.41

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0721000)

Modification: Disrupted | RMgm-2279

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4B5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158739

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	14	29
disruptive	7	36	32	54
missense	7	34	31	52

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	46	10	31
disruptive	13	83	44	112
missense	10	73	42	84

PlasmoDB Total SNPs: 254

Non-coding: 220 | Synonymous: 22 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 396 | Molecular Weight (kDa): 46.304

UniProt ID(s): C0H4B5

PDB ID(s): None

Isoelectric Point: 9.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A