PF3D7_0419000

Genome location: Pf3D7_04_v3:849,793..852,242(+)

Genome classification: Core

Function and Localization

Product Description: dynein regulatory complex protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005930	axoneme
Process	GO:0070286	axonemal dynein complex assembly
Process	GO:0060285	cilium-dependent cell motility
Process	GO:0003352	regulation of cilium movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	possibly expressed	0.02	0.98
Gametocyte	expressed	0.58	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0419000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.223 | MFS: -2.463 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1P7

"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=1.69) with 2QLL (Global RMSD=30.01)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103739

Most Similar Human Ortholog: F8W0R6

TM-align score: 0.71 | RMSD: 1.11

Seq Identity: 0.06 | Length: 35 / 440

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000139537	coiled-coil domain containing 65

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	14	36
disruptive	7	46	23	72
missense	7	41	23	69

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	46	28	30
disruptive	18	95	45	123
missense	12	85	39	99

PlasmoDB Total SNPs: 169

Non-coding: 135 | Synonymous: 26 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 440 | Molecular Weight (kDa): 53.467

UniProt ID(s): Q8I1P7

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039750	Dynein regulatory complex protein
PFam	N/A	N/A
Superfamily	N/A	N/A