Product Description: protein transport protein GOT1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | expressed | 0.02 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0419200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.125 | MFS: -3.136 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1P5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101505
Most Similar Human Ortholog: F5H6U7
TM-align score: 0.77 | RMSD: 2.66
Seq Identity: 0.36 | Length: 123 / 136
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111711 | golgi transport 1B |
| ENSG00000174567 | golgi transport 1A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 5 | 2 | 5 |
| disruptive | 0 | 5 | 7 | 11 |
| missense | 0 | 5 | 7 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 7 | 5 |
| disruptive | 3 | 17 | 8 | 31 |
| missense | 0 | 13 | 7 | 24 |
PlasmoDB Total SNPs: 105
Non-coding: 102 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 136 | Molecular Weight (kDa): 15.89
UniProt ID(s): Q8I1P5
PDB ID(s): None
Isoelectric Point: 10.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007305 | Vesicle transport protein, Got1/SFT2-like |
| PFam | PF04178 | Vesicle transport protein, Got1/SFT2-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 37754986 | Isolation and Identification of Non-Saccharomyces Yeast Producing 2-Phenylethanoland Study of the Ehrlich Pathway and Shikimate Pathway | Zhou R, Song Q, ..., Chen X | 10.3390/jof9090878 |