PF3D7_0419300

Genome location: Pf3D7_04_v3:854,488..857,207(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0033065	Rad51C-XRCC3 complex
Component	GO:0005657	replication fork
Process	GO:0045003	double-strand break repair via synthesis-dependent strand annealing
Process	GO:0071140	resolution of mitotic recombination intermediates
Process	GO:0090656	t-circle formation
Process	GO:0000722	telomere maintenance via recombination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	expressed	0.36	0.78
Schizont	expressed	0.21	0.86
Gametocyte	possibly expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0419300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.164 | MFS: -2.853 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1P4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_174320

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	17	10	17
disruptive	2	37	23	42
missense	2	34	18	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	29	15	19
disruptive	14	76	32	55
missense	8	54	27	37

PlasmoDB Total SNPs: 0

Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 346 | Molecular Weight (kDa): 41.785

UniProt ID(s): Q8I1P4

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF08423	DNA recombination and repair protein Rad51-like, C-terminal
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase