PF3D7_0419400

Genome location: Pf3D7_04_v3:857,875..866,312(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MRKKKKTCLVLLILSFLCFFYSSLS

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.26	0.85
Schizont	expressed	0.89	0.56
Gametocyte	expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0419400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.128 | #Insertions: 9

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0721500)

Relative Growth Rate: 0.40 ± 0.35
Confidence: 3.46

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1P3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533744

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	31	119	45	138
disruptive	90	377	217	448
missense	69	309	193	380

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	45	218	101	158
disruptive	169	771	325	662
missense	121	614	272	459

PlasmoDB Total SNPs: 311

Non-coding: 81 | Synonymous: 117 | Nonsynonymous: 112 | Stop Codon: 1

Protein Information

Protein Length: 2472 | Molecular Weight (kDa): 296.455

UniProt ID(s): Q8I1P3

PDB ID(s): None

Isoelectric Point: 6.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104