PF3D7_0419600 (RANBP1)

Genome location: Pf3D7_04_v3:869,788..872,102(+)

Genome classification: Core

Function and Localization

Product Description: ran-specific GTPase-activating protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005643	nuclear pore
Component	GO:0005634	nucleus
Function	GO:0005525	GTP binding
Function	GO:0003924	GTPase activity
Process	GO:0006260	DNA replication
Process	GO:0006405	RNA export from nucleus
Process	GO:0006606	protein import into nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.51	0.37
Trophozoite	expressed	1.44	0.34
Schizont	expressed	0.74	0.59
Gametocyte	expressed	0.98	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0419600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -1.968 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q76NN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101736

Most Similar Human Ortholog: C9JIC6

TM-align score: 0.89 | RMSD: 0.56

Seq Identity: 0.61 | Length: 49 / 280

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000099901	RAN binding protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	13	6	11
disruptive	1	13	10	32
missense	1	7	9	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	25	7	15
disruptive	6	49	25	105
missense	1	34	17	55

PlasmoDB Total SNPs: 167

Non-coding: 153 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 280 | Molecular Weight (kDa): 33.196

UniProt ID(s): Q76NN6, Q8WT07

PDB ID(s): None

Isoelectric Point: 4.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000156	Ran binding domain
PFam	PF00638	Ran binding domain
Superfamily	SSF50729	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104