Product Description: 60S ribosomal protein L7ae/L30e, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031429 | box H/ACA snoRNP complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Function | GO:0003723 | RNA binding |
| Function | GO:0034513 | box H/ACA snoRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000469 | cleavage involved in rRNA processing |
| Process | GO:0000470 | maturation of LSU-rRNA |
| Process | GO:0031118 | rRNA pseudouridine synthesis |
| Process | GO:0031120 | snRNA pseudouridine synthesis |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.81 | 0.63 |
| Trophozoite | expressed | 0.63 | 0.67 |
| Schizont | expressed | 0.16 | 0.89 |
| Gametocyte | possibly expressed | 0.48 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0419800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.208 | MFS: -3.3 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1P0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102271
Most Similar Human Ortholog: Q9NX24
TM-align score: 0.77 | RMSD: 2.12
Seq Identity: 0.27 | Length: 133 / 236
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145912 | NHP2 ribonucleoprotein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 118
Non-coding: 109 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 236 | Molecular Weight (kDa): 27.563
UniProt ID(s): Q8I1P0
PDB ID(s): None
Isoelectric Point: 9.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004038 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| InterPro | IPR018492 | Ribosomal protein L7Ae/L8/Nhp2 family |
| InterPro | IPR029064 | 50S ribosomal protein L30e-like |
| PFam | PF01248 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| Superfamily | SSF55315 | 50S ribosomal protein L30e-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |