About Gene List

PF3D7_0420000

Genome location: Pf3D7_04_v3:893,948..906,047(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0016020 membrane
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.05 0.26
Trophozoite expressed 1.53 0.31
Schizont expressed 0.88 0.56
Gametocyte expressed 1.28 0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0420000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.265 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110181

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 49 154 72 180
disruptive 289 636 325 734
missense 150 427 264 572

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 68 290 121 224
disruptive 474 1249 516 977
missense 222 906 399 659

PlasmoDB Total SNPs: 867

Non-coding: 193 | Synonymous: 249 | Nonsynonymous: 414 | Stop Codon: 11

Protein Information

Protein Length: 3370 | Molecular Weight (kDa): 401.144

UniProt ID(s): Q8I1N9

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011124 Zinc finger, CW-type
PFam PF07496 Zinc finger, CW-type
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108