PF3D7_0420200 (ACPS)

Genome location: Pf3D7_04_v3:909,409..912,119(+)

Genome classification: Core

Function and Localization

Product Description: holo-[acyl-carrier-protein] synthase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.8.7 (Holo-[acyl-carrier-protein] synthase)

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0420200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.234 | MFS: -2.64 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1N7

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.14) with 3QMN (Global RMSD=6.11)

BRENDA EC Inhibitors:

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_101866

No human ortholog(s)

Protein Information

Protein Length: 594 | Molecular Weight (kDa): 70.386

UniProt ID(s): Q8I1N7

PDB ID(s): 2FQ0, 2FQ2

Isoelectric Point: 9.61

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 162

Non-coding: 105 | Synonymous: 34 | Nonsynonymous: 23 | Stop Codon: 0