Product Description: ribosome-recycling factor
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0043023 | ribosomal large subunit binding |
| Process | GO:0032790 | ribosome disassembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.42 | 0.75 |
| Schizont | expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0420400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.164 | MFS: -2.754 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0521800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0521800)
Modification: Disrupted | RMgm-2041
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFQ7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101101
Most Similar Human Ortholog: Q96E11
TM-align score: 0.55 | RMSD: 3.43
Seq Identity: 0.15 | Length: 182 / 266
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148187 | mitochondrial ribosome recycling factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 9 | 7 | 11 |
| disruptive | 8 | 22 | 12 | 39 |
| missense | 7 | 22 | 12 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 17 | 6 | 17 |
| disruptive | 14 | 56 | 36 | 65 |
| missense | 13 | 40 | 24 | 48 |
PlasmoDB Total SNPs: 66
Non-coding: 47 | Synonymous: 7 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 266 | Molecular Weight (kDa): 31.571
UniProt ID(s): Q8IFQ7
PDB ID(s): None
Isoelectric Point: 10.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002661 | Ribosome recycling factor |
| InterPro | IPR023584 | Ribosome recycling factor domain |
| InterPro | IPR036191 | RRF superfamily |
| PFam | PF01765 | Ribosome recycling factor domain |
| Superfamily | SSF55194 | RRF superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23614815 | Recycling factors for ribosome disassembly in the apicoplast and mitochondrion ofPlasmodium falciparum. | Gupta A, Mir SS, ..., Habib S | 10.1111/mmi.12230 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |