PF3D7_0420500

Genome location: Pf3D7_04_v3:930,314..931,842(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.06	0.96
Schizont	no data	0.39	0.78
Gametocyte	no data	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0420500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.962 | MFS: -0.762 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4B7

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.27) with 5UJ7 (Global RMSD=8.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532795

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	6	5	7
disruptive	2	19	9	28
missense	2	17	8	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	14	7	10
disruptive	4	44	24	64
missense	3	33	20	40

PlasmoDB Total SNPs: 104

Non-coding: 96 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 198 | Molecular Weight (kDa): 23.897

UniProt ID(s): C0H4B7

PDB ID(s): None

Isoelectric Point: 8.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029021	Protein-tyrosine phosphatase-like
PFam	N/A	N/A
Superfamily	SSF52799	Protein-tyrosine phosphatase-like