About Gene List

PF3D7_0420600 (AKIT6)

Genome location: Pf3D7_04_v3:932,373..934,499(+)

Genome classification: Core

Function and Localization

Product Description: apicomplexan kinetochore protein 6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000776 kinetochore
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.08 0.96
Trophozoite no data 0.65 0.64
Schizont no data 1.06 0.44
Gametocyte no data 0.70 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0420600

Resistome Missense Mutations: H362Q

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.265 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0522000)

  • Relative Growth Rate: 0.09 ± 0.10
  • Confidence: 6.03

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0522000)

Modification: Tagged | RMgm-5118

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A146LZZ4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533004

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 18 9 21
disruptive 40 56 25 76
missense 18 35 18 64

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 39 18 29
disruptive 58 119 58 132
missense 26 75 43 75

PlasmoDB Total SNPs: 164

Non-coding: 67 | Synonymous: 55 | Nonsynonymous: 41 | Stop Codon: 1

Protein Information

Protein Length: 593 | Molecular Weight (kDa): 69.679

UniProt ID(s): A0A146LZZ4

PDB ID(s): None

Isoelectric Point: 5.74

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
36006241 Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation Brusini L, Dos Santos Pacheco N, ..., Brochet M 10.1083/jcb.202111084