PF3D7_0421700

Genome location: Pf3D7_04_v3:987,842..994,360(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.05	0.97
Trophozoite	no data	0.01	1.00
Schizont	no data	0.02	0.99
Gametocyte	no data	0.82	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0421700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.866 | #Insertions: 14

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0522100)

Modification: Disrupted | RMgm-2043

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4B8

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=2.81) with 6KCL (Global RMSD=32.19)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532738

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	48	75	42	117
disruptive	118	251	124	341
missense	98	224	116	295

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	60	144	74	126
disruptive	177	497	190	466
missense	129	420	162	370

PlasmoDB Total SNPs: 317

Non-coding: 122 | Synonymous: 83 | Nonsynonymous: 110 | Stop Codon: 2

Protein Information

Protein Length: 1936 | Molecular Weight (kDa): 234.813

UniProt ID(s): C0H4B8

PDB ID(s): None

Isoelectric Point: 9.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A