PF3D7_0421900

Genome location: Pf3D7_04_v3:997,240..997,455(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKTVYFIFFFHILLMYCYFCDH

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.05	0.97
Trophozoite	no data	0.00	1.00
Schizont	no data	0.02	0.99
Gametocyte	no data	1.06	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0421900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.4 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0522300)

Relative Growth Rate: 0.98 ± 0.16
Confidence: 5.02

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0522300)

Modification: Disrupted | RMgm-2044

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFP7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532692

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	2	1	3
disruptive	2	7	3	15
missense	2	6	3	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	7	0	6
disruptive	4	13	10	26
missense	3	12	8	23

PlasmoDB Total SNPs: 10

Non-coding: 0 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 71 | Molecular Weight (kDa): 8.552

UniProt ID(s): Q8IFP7

PDB ID(s): None

Isoelectric Point: 4.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A