Product Description: transmembrane emp24 domain-containing protein, putative
SignalP Peptide: MYHVTRSFVLFLILFIFFHVAG
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0020011 | apicoplast |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0007030 | Golgi organization |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.34 | 0.84 |
| Trophozoite | expressed | 1.05 | 0.46 |
| Schizont | expressed | 0.25 | 0.85 |
| Gametocyte | not expressed | 0.30 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0422100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -2.978 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1413000)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0522500)
Modification: Disrupted | RMgm-4960
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFP5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101558
Most Similar Human Ortholog: F5GX39
TM-align score: 0.56 | RMSD: 3.17
Seq Identity: 0.19 | Length: 85 / 385
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000086598 | transmembrane p24 trafficking protein 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 10 | 15 | 23 |
| disruptive | 22 | 55 | 31 | 57 |
| missense | 13 | 35 | 22 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 31 | 18 | 21 |
| disruptive | 38 | 102 | 49 | 128 |
| missense | 18 | 69 | 36 | 72 |
PlasmoDB Total SNPs: 103
Non-coding: 60 | Synonymous: 16 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 385 | Molecular Weight (kDa): 44.93
UniProt ID(s): Q8IFP5
PDB ID(s): None
Isoelectric Point: 6.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009038 | GOLD domain |
| InterPro | IPR015720 | TMP21-related |
| PFam | PF01105 | GOLD domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33515807 | Systematic Identification of Plasmodium Falciparum Sporozoite Membrane ProteinInteractions Reveals an Essential Role for the p24 Complex in Host Infection. | Knockel J, Dundas K, ..., Wright GJ | 10.1074/mcp.RA120.002432 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |