PF3D7_0422200

Genome location: Pf3D7_04_v3:1,003,768..1,018,837(-)

Genome classification: Core

Function and Localization

Product Description: erythrocyte membrane-associated antigen

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.59	0.74
Trophozoite	possibly expressed	1.19	0.44
Schizont	possibly expressed	1.13	0.47
Gametocyte	possibly expressed	2.04	0.18

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0422200

Resistome Missense Mutations: K804R

Resistome Compounds with Missense Mutations: MMV019313

Resistome # Samples with Disruptive Mutations: 5 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.322 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139065

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	41	220	135	305
disruptive	263	805	388	974
missense	144	651	339	802

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	85	446	196	288
disruptive	490	1639	666	1277
missense	251	1318	546	896

PlasmoDB Total SNPs: 808

Non-coding: 204 | Synonymous: 294 | Nonsynonymous: 307 | Stop Codon: 3

Protein Information

Protein Length: 4261 | Molecular Weight (kDa): 508.543

UniProt ID(s): Q8IFP4, Q9GVB6

PDB ID(s): None

Isoelectric Point: 9.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR043519	Nucleotidyltransferase superfamily
PFam	N/A	N/A
Superfamily	SSF81301	Nucleotidyltransferase superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104