PF3D7_0422800 (SR12)

Genome location: Pf3D7_04_v3:1,042,564..1,044,896(+)

Genome classification: Core

Function and Localization

Product Description: serpentine receptor 12, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.03	0.99
Trophozoite	expressed	0.31	0.80
Schizont	expressed	0.30	0.81
Gametocyte	expressed	0.20	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0422800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.746 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0523200)

Relative Growth Rate: 0.97 ± 0.12
Confidence: 5.59

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0524600)

Modification: Disrupted | RMgm-4759

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4C0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156366

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	22	16	32
disruptive	8	40	18	69
missense	8	37	17	63

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	48	14	24
disruptive	13	107	45	121
missense	13	85	38	80

PlasmoDB Total SNPs: 189

Non-coding: 167 | Synonymous: 16 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 470 | Molecular Weight (kDa): 56.053

UniProt ID(s): C0H4C0

PDB ID(s): None

Isoelectric Point: 9.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019336	Intimal thickness related receptor, IRP
PFam	PF10192	Intimal thickness related receptor, IRP
Superfamily	N/A	N/A