PF3D7_0422900

Genome location: Pf3D7_04_v3:1,045,301..1,046,988(+)

Genome classification: Core

Function and Localization

Product Description: methyltransferase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.17	0.92
Trophozoite	not expressed	0.10	0.94
Schizont	not expressed	0.13	0.93
Gametocyte	expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0422900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.177 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFN7

"Best" AlphaFill ligand hit: G3H (glyceraldehyde-3-phosphate, Local RMSD=1.98) with 4ZEX (Global RMSD=14.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215323

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	18	5	10
disruptive	2	21	17	40
missense	2	21	16	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	21	7	20
disruptive	6	55	36	76
missense	5	45	30	61

PlasmoDB Total SNPs: 129

Non-coding: 121 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 242 | Molecular Weight (kDa): 28.778

UniProt ID(s): Q8IFN7

PDB ID(s): None

Isoelectric Point: 9.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
PFam	PF13489	N/A
Superfamily	SSF53335	S-adenosyl-L-methionine-dependent methyltransferase

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104