PF3D7_0423000

Genome location: Pf3D7_04_v3:1,047,470..1,048,843(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.19	0.87
Schizont	not expressed	0.19	0.87
Gametocyte	not expressed	0.28	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0423000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.847 | MFS: -1.845 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533435

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	15	6	21
disruptive	13	56	19	53
missense	9	49	17	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	32	14	22
disruptive	25	115	35	61
missense	17	87	28	39

PlasmoDB Total SNPs: 79

Non-coding: 58 | Synonymous: 9 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 260 | Molecular Weight (kDa): 31.011

UniProt ID(s): Q8IFN6

PDB ID(s): None

Isoelectric Point: 10.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A