PF3D7_0423100

Genome location: Pf3D7_04_v3:1,048,879..1,050,294(-)

Genome classification: Core

Function and Localization

Product Description: AP-4 complex subunit sigma, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043231	intracellular membrane-bounded organelle
Component	GO:0030141	secretory granule
Component	GO:0030133	transport vesicle
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.45	0.78
Trophozoite	expressed	0.72	0.60
Schizont	expressed	0.27	0.82
Gametocyte	expressed	0.67	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0423100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.223 | MFS: -2.931 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFN5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q3ZBB6	AP-4 complex subunit sigma-1	Bos taurus	HOGENOM, OMA, OrthoDB, OrthoMCL BLAST	NSC_11603174
Q9Y587	AP-4 complex subunit sigma-1	Homo sapiens	OMA, OrthoDB, OrthoMCL BLAST	PRUCALOPRIDESR 147778US11649248, Example 1US11649248, Example 2...

Orthology Information

Ortholog Group (OrthoMCL): OG6_105022

Most Similar Human Ortholog: Q9Y587

TM-align score: 0.99 | RMSD: 0.49

Seq Identity: 0.55 | Length: 144 / 146

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000100478	adaptor related protein complex 4 subunit sigma 1

Protein Information

Protein Length: 146 | Molecular Weight (kDa): 17.449

UniProt ID(s): Q8IFN5

PDB ID(s): None

Isoelectric Point: 4.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011012	Longin-like domain superfamily
InterPro	IPR016635	Adaptor protein complex, sigma subunit
InterPro	IPR022775	AP complex, mu/sigma subunit
PFam	PF01217	AP complex, mu/sigma subunit
Superfamily	SSF64356	Longin-like domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	7	3	6
disruptive	2	4	5	9
missense	2	4	5	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	20	3	12
disruptive	2	16	11	32
missense	2	13	10	24

PlasmoDB Total SNPs: 123

Non-coding: 119 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0