PF3D7_0423200

Genome location: Pf3D7_04_v3:1,050,249..1,051,258(+)

Genome classification: Core

Function and Localization

Product Description: BSD-domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.11	0.92
Schizont	possibly expressed	0.10	0.93
Gametocyte	not expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0423200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.349 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFN4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136486

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	4	4	7
disruptive	1	7	3	16
missense	1	7	3	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	6	8
disruptive	2	26	10	46
missense	2	19	7	29

PlasmoDB Total SNPs: 72

Non-coding: 68 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 136 | Molecular Weight (kDa): 16.582

UniProt ID(s): Q8IFN4

PDB ID(s): None

Isoelectric Point: 5.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005607	BSD domain
PFam	PF03909	BSD domain
Superfamily	SSF140383	N/A