PF3D7_0423300

Genome location: Pf3D7_04_v3:1,051,095..1,053,352(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.09	0.95
Schizont	expressed	1.82	0.29
Gametocyte	expressed	1.03	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0423300

Resistome Missense Mutations: L234Q, L240I

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.696 | MFS: -2.396 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFN3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533309

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	17	19	24
disruptive	20	96	51	113
missense	13	71	33	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	40	25	27
disruptive	73	192	81	155
missense	39	128	57	90

PlasmoDB Total SNPs: 128

Non-coding: 51 | Synonymous: 52 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 476 | Molecular Weight (kDa): 58.351

UniProt ID(s): Q8IFN3

PDB ID(s): None

Isoelectric Point: 10.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A