Genome location: Pf3D7_04_v3:1,055,314..1,056,674(+)
Genome classification: Core
Product Description: apical asparagine-rich protein AARP
SignalP Peptide: MWKFITIIIFSIYYIDG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0020008 | rhoptry |
| Component | GO:1990225 | rhoptry neck |
| Function | GO:0046789 | host cell surface receptor binding |
| Process | GO:0098609 | cell-cell adhesion |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | expressed | 1.65 | 0.37 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0423400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.519 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFN2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 9 | 17 |
| disruptive | 19 | 69 | 15 | 47 |
| missense | 7 | 34 | 9 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 12 | 22 |
| disruptive | 45 | 99 | 30 | 74 |
| missense | 19 | 52 | 16 | 40 |
PlasmoDB Total SNPs: 120
Non-coding: 57 | Synonymous: 38 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 217 | Molecular Weight (kDa): 24.638
UniProt ID(s): A0A2S1Q7N9, A0A2S1Q7P2, Q8IFN2
PDB ID(s): None
Isoelectric Point: 4.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 18320051 | Identification and characterization of a novel Plasmodium falciparum merozoiteapical protein involved in erythrocyte binding and invasion. | Wickramarachchi T, Devi YS, Mohmmed A, Chauhan VS | 10.1371/journal.pone.0001732 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |