Genome location: Pf3D7_04_v3:1,058,888..1,061,603(+)
Genome classification: Core
Product Description: glideosome associated protein with multiple membrane spans 2
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0070258 | inner membrane pellicle complex |
| Component | GO:0032991 | protein-containing complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.18 | 0.88 |
| Schizont | expressed | 1.20 | 0.44 |
| Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0423500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.773 | MFS: -2.279 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFN1
"Best" AlphaFill ligand hit: UMQ (undecyl-maltoside, Local RMSD=0.66) with 4HE8 (Global RMSD=19.97)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 21 | 14 | 15 |
| disruptive | 0 | 10 | 5 | 16 |
| missense | 0 | 9 | 5 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 42 | 11 | 22 |
| disruptive | 2 | 33 | 21 | 80 |
| missense | 0 | 26 | 16 | 65 |
PlasmoDB Total SNPs: 200
Non-coding: 188 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 372 | Molecular Weight (kDa): 42.618
UniProt ID(s): Q8IFN1
PDB ID(s): None
Isoelectric Point: 4.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021691 | Protein of unknown function DUF3273 |
| PFam | PF11677 | Protein of unknown function DUF3273 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19465059 | A complex of three related membrane proteins is conserved on malarial merozoites. | Rayavara K, Rajapandi T, ..., Desai SA | 10.1016/j.molbiopara.2009.05.006 |
| 19561073 | A novel family of Apicomplexan glideosome-associated proteins with an innermembrane-anchoring role. | Bullen HE, Tonkin CJ, ..., Gilson PR | 10.1074/jbc.M109.036772 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
| 28985225 | Disrupting assembly of the inner membrane complex blocks Plasmodium falciparumsexual stage development. | Parkyn Schneider M, Liu B, ..., Dixon MWA | 10.1371/journal.ppat.1006659 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34324609 | Plasmodium falciparum PhIL1-associated complex plays an essential role inmerozoite reorientation and invasion of host erythrocytes. | Saini E, Sheokand PK, ..., Malhotra P | 10.1371/journal.ppat.1009750 |