About Gene List

PF3D7_0423600

Genome location: Pf3D7_04_v3:1,061,719..1,067,023(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.16 0.50
Trophozoite expressed 1.42 0.34
Schizont expressed 0.93 0.51
Gametocyte expressed 1.50 0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0423600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.834 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFN0

"Best" AlphaFill ligand hit: HH2 ([pterin-6-yl methanyl]-phosphonophosphate, Local RMSD=0.67) with 5Z79 (Global RMSD=9.93)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127576

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 28 76 39 80
disruptive 108 275 118 306
missense 38 199 100 244

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 40 137 47 99
disruptive 187 493 202 410
missense 78 365 154 296

PlasmoDB Total SNPs: 277

Non-coding: 30 | Synonymous: 130 | Nonsynonymous: 117 | Stop Codon: 0

Protein Information

Protein Length: 1612 | Molecular Weight (kDa): 190.947

UniProt ID(s): Q8IFN0

PDB ID(s): None

Isoelectric Point: 7.87

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF58104 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104