Genome location: Pf3D7_04_v3:1,069,829..1,072,039(-)
Genome classification: Core
Product Description: early transcribed membrane protein 4
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020005 | symbiont-containing vacuole membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.90 |
| Trophozoite | expressed | 0.52 | 0.78 |
| Schizont | expressed | 1.41 | 0.42 |
| Gametocyte | expressed | 1.90 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0423700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFM9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 3 | 5 | 5 |
| disruptive | 7 | 5 | 7 | 13 |
| missense | 7 | 5 | 7 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 11 | 4 | 9 |
| disruptive | 8 | 29 | 20 | 34 |
| missense | 8 | 22 | 16 | 22 |
PlasmoDB Total SNPs: 128
Non-coding: 122 | Synonymous: 1 | Nonsynonymous: 4 | Stop Codon: 1
Protein Length: 136 | Molecular Weight (kDa): 14.891
PDB ID(s): None
Isoelectric Point: 10.16
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006389 | Early transcribed membrane protein (ETRAMP) |
| PFam | PF09716 | Early transcribed membrane protein (ETRAMP) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 12686607 | etramps, a new Plasmodium falciparum gene family coding for developmentallyregulated and highly charged membrane proteins located at the parasite-host cellinterface. | Spielmann T, Fergusen DJ, Beck HP | 10.1091/mbc.e02-04-0240 |
| 31856917 | Evaluation of antibody responses to the early transcribed membrane protein familyin Plasmodium vivax | Lee SK, Han JH, ..., Han ET | 10.1186/s13071-019-3846-4 |