PF3D7_0423900

Genome location: Pf3D7_04_v3:1,077,575..1,078,515(-)

Genome classification: Core

Function and Localization

Product Description: probable protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.34	0.83
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.07	0.96
Gametocyte	possibly expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0423900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.46 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFM7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532577

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	5	4	8
disruptive	21	36	19	44
missense	10	24	13	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	12	3	13
disruptive	29	72	27	44
missense	12	49	18	20

PlasmoDB Total SNPs: 114

Non-coding: 88 | Synonymous: 11 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 140 | Molecular Weight (kDa): 16.117

UniProt ID(s): Q8IFM7

PDB ID(s): None

Isoelectric Point: 4.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A