PF3D7_0424000

Genome location: Pf3D7_04_v3:1,080,176..1,082,321(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Function	GO:0005515	protein binding
Function	GO:0044877	protein-containing complex binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.08	0.96
Trophozoite	expressed	0.14	0.92
Schizont	expressed	0.04	0.98
Gametocyte	not expressed	0.03	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0424000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: 1.309 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H495

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179328

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	22	8	18
disruptive	25	55	46	76
missense	19	52	41	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	38	8	20
disruptive	37	134	48	100
missense	27	114	41	71

PlasmoDB Total SNPs: 174

Non-coding: 140 | Synonymous: 16 | Nonsynonymous: 17 | Stop Codon: 1

Protein Information

Protein Length: 347 | Molecular Weight (kDa): 40.867

UniProt ID(s): C0H495

PDB ID(s): None

Isoelectric Point: 4.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
29155505	PHISTc protein family members localize to different subcellular organelles andbind Plasmodium falciparum major virulence factor PfEMP-1.	Kumar V, Kaur J, ..., Hora R	10.1111/febs.14340
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g