Genome location: Pf3D7_04_v3:1,099,303..1,107,445(+)
Genome classification: Core
Product Description: surface-associated interspersed protein 4.2 (SURFIN 4.2)
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0009986 | cell surface |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0044228 | host cell surface |
| Component | GO:1990225 | rhoptry neck |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0003779 | actin binding |
| Function | GO:0046812 | host cell surface binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0030507 | spectrin binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.16 | 0.92 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.09 | 0.95 |
| Gametocyte | not expressed | 0.06 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0424400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.171 | #Insertions: 6
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFM2
"Best" AlphaFill ligand hit: CHT (choline ion, Local RMSD=0.18) with 7E2B (Global RMSD=32.65)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 61 | 38 | 90 |
| disruptive | 299 | 293 | 179 | 380 |
| missense | 276 | 253 | 140 | 311 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 44 | 111 | 51 | 105 |
| disruptive | 369 | 575 | 236 | 435 |
| missense | 313 | 460 | 180 | 311 |
PlasmoDB Total SNPs: 611
Non-coding: 72 | Synonymous: 129 | Nonsynonymous: 405 | Stop Codon: 5
Protein Length: 2380 | Molecular Weight (kDa): 286.414
UniProt ID(s): A0A060N135, A0A2H4THN6, A0A348FV63, A0A348FV73, A0A348FV78, A0A348FV79, D9HNK5, D9HNL0, D9HNM6, D9HNM9, D9HNN7, D9HNP1, D9HNP8, D9HNR3, D9HNR9, D9HNS0, H7CFZ6, Q3HSE1, Q4R1H0, Q8IFM2
PDB ID(s): None
Isoelectric Point: 5.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15939796 | SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites andinfected erythrocytes. | Winter G, Kawai S, ..., Wahlgren M | 10.1084/jem.20041392 |
| 21616162 | PEXEL-independent trafficking of Plasmodium falciparum SURFIN4.2 to theparasite-infected red blood cell and Maurer's clefts. | Alexandre JS, Yahata K, ..., Kaneko O | 10.1016/j.parint.2011.05.003 |
| 28320404 | Tryptophan-rich domains of Plasmodium falciparum SURFIN(4.2) and Plasmodium vivaxPvSTP2 interact with membrane skeleton of red blood cell. | Zhu X, He Y, ..., Cao Y | 10.1186/s12936-017-1772-5 |
| 30092030 | SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP)contributes to merozoite invasion. | Quintana MDP, Ch'ng JH, ..., Wahlgren M | 10.1371/journal.pone.0201669 |
| 22212242 | Stable allele frequency distribution of the polymorphic region of SURFIN(4.2) inPlasmodium falciparum isolates from Thailand | Kaewthamasorn M, Yahata K, ..., Kaneko O | 10.1016/j.parint.2011.12.003 |