About Gene List

PF3D7_0424600

Genome location: Pf3D7_04_v3:1,112,736..1,117,250(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb)

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:1903561 extracellular vesicle
Component GO:0044538 host cell periphery
Component GO:0044228 host cell surface
Component GO:0005634 nucleus
Process GO:0020035 cytoadherence to microvasculature, mediated by symbiont protein

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.72 0.15
Trophozoite expressed 1.17 0.45
Schizont expressed 0.73 0.62
Gametocyte not expressed 0.51 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0424600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -0.203 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFM0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 1
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 262

Non-coding: 238 | Synonymous: 10 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 309 | Molecular Weight (kDa): 35.962

UniProt ID(s): Q8IFM0

PDB ID(s): None

Isoelectric Point: 8.75

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
18614010 Exported proteins required for virulence and rigidity of Plasmodiumfalciparum-infected human erythrocytes. Maier AG, Rug M, ..., Cowman AF 10.1016/j.cell.2008.04.051
25106850 A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. Tarr SJ, Moon RW, Hardege I, Osborne AR 10.1016/j.molbiopara.2014.07.011
28944300 Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. Abdi A, Yu L, ..., Rayner J 10.12688/wellcomeopenres.11910.2
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332