About Gene List

PF3D7_0424800

Genome location: Pf3D7_04_v3:1,123,975..1,125,348(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.11 0.95
Trophozoite not expressed 0.01 0.99
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0424800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.216 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFL8

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.36) with 4ETP (Global RMSD=19.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 11 1 11
disruptive 8 57 16 58
missense 8 48 12 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 19 5 17
disruptive 27 87 32 131
missense 21 64 20 67

PlasmoDB Total SNPs: 81

Non-coding: 26 | Synonymous: 34 | Nonsynonymous: 19 | Stop Codon: 2

Protein Information

Protein Length: 314 | Molecular Weight (kDa): 36.685

UniProt ID(s): Q01423, Q8IFL8

PDB ID(s): None

Isoelectric Point: 6.11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12