About Gene List

PF3D7_0424900

Genome location: Pf3D7_04_v3:1,127,257..1,129,353(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTa), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.25 0.91
Trophozoite not expressed 0.05 0.98
Schizont not expressed 0.04 0.97
Gametocyte not expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0424900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.07 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFL7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 11 5 3
disruptive 14 37 15 26
missense 12 34 15 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 18 6 12
disruptive 16 72 24 76
missense 14 61 17 38

PlasmoDB Total SNPs: 131

Non-coding: 98 | Synonymous: 18 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 283 | Molecular Weight (kDa): 33.207

UniProt ID(s): Q8IFL7

PDB ID(s): None

Isoelectric Point: 8.85

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12