PF3D7_0425100

Genome location: Pf3D7_04_v3:1,134,415..1,135,394(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp6), unknown function

SignalP Peptide: MSKVLIFFTNFLLIYL

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0425100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.866 | MFS: -2.541 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFL4

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 99

Non-coding: 26 | Synonymous: 16 | Nonsynonymous: 57 | Stop Codon: 0

Protein Information

Protein Length: 205 | Molecular Weight (kDa): 24.108

UniProt ID(s): Q8IFL4

PDB ID(s): None

Isoelectric Point: 7.32

Protein Domain Annotations: