About Gene List

PF3D7_0425200

Genome location: Pf3D7_04_v3:1,136,443..1,137,793(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp15), unknown function

SignalP Peptide: MNFCSFIFLFTVTLRVILA

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.07 0.97
Trophozoite not expressed 0.01 1.00
Schizont possibly expressed 0.01 1.00
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0425200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.74 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFL3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160721

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 8 5 2
disruptive 81 22 14 28
missense 45 15 14 20

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 13 3 4
disruptive 94 61 25 57
missense 49 42 19 30

PlasmoDB Total SNPs: 183

Non-coding: 65 | Synonymous: 29 | Nonsynonymous: 89 | Stop Codon: 0

Protein Information

Protein Length: 230 | Molecular Weight (kDa): 27.017

UniProt ID(s): Q8IFL3

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12