PF3D7_0425400

Genome location: Pf3D7_04_v3:1,143,992..1,144,824(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: Plasmodium exported protein (PHISTa), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0425400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.73 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IFL1

"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=1.37) with 2XI3 (Global RMSD=21.73)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 108

Non-coding: 22 | Synonymous: 24 | Nonsynonymous: 61 | Stop Codon: 1

Protein Information

Protein Length: 231 | Molecular Weight (kDa): 27.535

UniProt ID(s): Q8IFL1

PDB ID(s): None

Isoelectric Point: 8.06

Protein Domain Annotations: